Progress of Cryogenics and Isotopes Separation , ISSN: 1582-2575
2017, Volume 20, Issue 2

Obtaining of an active product based on yeast biomass by fermentation of a waste from winemaking process from Oprisor area

Iuliana Diana Barbulescu 1 , Razvan Ionut Teodorescu 2 , Veronica Sanda Chedea 3 , Liviu Grigorica 4 , Gabriel Roceanu 5 , Simona Ioana Marinescu 1 , Mihai Frincu 1 , Mădălina Georgiana Albu Kaya 6 , Alexandru Cîrîc 7 , Petruta Mihaela Matei 2,8 , Radu Tamaian 9,10,11 , Corina Dumitrache 2 , Valerica Tudor 2 , Mihaela Begea 2*

1 Pharmacorp Innovation SRL, Bucharest, Romania
2 University of Agronomic Sciences and Veterinary Medicine Bucharest, Romania
3 National Institute of Research and Development for Biology and Animal Nutrition, Balotesti, Romania
4 Bevitech SRL, Bucharest, Romania
5 Carl Reh Winery SRL, Bucharest
6 INCDTP - Division Leather and Footwear Research Institute, Collagen Department, Bucharest, Romania
7 University Politehnica of Bucharest, Romania
8 Universidad de Valladolid ETSIIA, Spain
9 National Research and Development Institute for Cryogenics and Isotopic Technologies - ICSI Rm. Valcea, Uzinei Street no. 4, PO Box Râureni 7, 240050, Râmnicu Vâlcea, Romania
10 Biotech Corp SRL, Râmnicu Vâlcea, Romania
11 University of Bucharest, Faculty of Physics, 3Nano-SAE Research Centre, Bucharest-Măgurele, Romania

*Corresponding authors: Mihaela Begea, E-mail:; Barbulescu Iuliana Diana, e-mail:

Published: 2017


This paper describes the use of dry grape residue as a fermentation substrate for obtaining yeast biomass enriched in proteins and polyphenols. Yeast isolates from the wine region Oprișor (Mehedinți county) have been used as solid and liquid pure culture in order to obtain dried lyophilized yeast biomass enriched in polyphenols with high content in protein and with high antioxidant activity. The experiments were conducted both in  light and dark to verify the influence of light on the total polyphenols content. It is noted that in the case of the fermentation of a culture medium containing dry grape residue, the polyphenol’s content was higher in the dark than in the light. By the fermentation of the culture medium based on dry waste, it is observed that the protein content increases in the dry yeast biomass.


waste, biomass, marc, protein, total polyphenols, antioxidant activity

Tag search waste biomass marc protein total polyphenols antioxidant activity